MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
Identifieur interne : 003165 ( Main/Exploration ); précédent : 003164; suivant : 003166MEIC—A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests
Auteurs : Inger Bondesson [Suède] ; Björn Ekwall [Suède] ; Sven Hellberg [Suède] ; Lennart Romert [Suède] ; Kjell Stenberg [Suède] ; Erik Walum [Suède]Source :
- Cell Biology and Toxicology [ 0742-2091 ] ; 1989-11-01.
English descriptors
- KwdEn :
- Teeft :
- Acute toxicity, Animal tests, Atla, Basal, Basal cytotoxic concentration, Basal cytotoxicity, Bernson, Biotransformation, Blood concentration, Blood concentrations, Bondesson, Carcinogenicity tests, Cell biology, Cell lines, Cytotoxic, Cytotoxicity, Cytotoxicity tests, Different types, Dos, Dosage, Drug toxicity, Ekwall, Evaluation approach, Excretion, Food chem, General toxicity, Gross toxicity, Hellberg, Human hepatocytes, Human toxicity, Irritancy, Lethal dosage, Local irritancy, Local toxicity, Mechanistic, Meic, Meic study, Modeling, Multivariate, Multivariate data analysis, Physicochemical data, Predictivity, Quantitative toxicity, Reference chemicals, Romert, Stenberg, Stockholm, Such batteries, Sulfate, Systemic toxicity, Toxic, Toxic concentrations, Toxic dosage, Toxic effects, Toxic mechanisms, Toxicity, Toxicity testing, Toxicokinetic, Toxicokinetic models, Toxicol, Toxicology, Validation, Various cells, Walum, Whole model.
Abstract
Abstract: A new international project to evaluate the relevance for human systemic and local toxicity of in vitro tests of general toxicity of chemicals has been organized by the Scandinavian Society of Cell Toxicology under the title 1Multicenter Evaluation of In Vitro Cytotoxicity (MEIC). The basic assumptions underlying the project, as well as the practical goals and the design of the program are outlined. The list of the first 50 reference chemicals is presented. The chemicals are an otherwise unbiased selection of compounds with known human acutely lethal dosage and blood concentrations, including LD50-values in the rat or mouse. Most agents also have other data on human toxicity and toxicokinetics, including more extensive animal toxicity data. International laboratories already using or developing in vitro tests of various partial aspects of general toxicity are invited to test the substances, the results of which will be evaluated by us. The predictivity of the in vitro results for both partial and gross human toxicity data will be determined with combined use of univariate regression analysis and soft multivariate modeling. The predictivity of the in vitro results will be compared with the predictivity of conventional animal tests for the same chemicals. Finally, batteries of tests with optimal prediction power for various types of human toxicity will be selected. The need for and possible uses of such batteries are discussed. TABLE 1 The First 50 Reference Chemicals of the MEIC Project 1. Acetaminophen 26. Arsenic trioxide 2. Aspirin 27. Cupric sulfate 3. Ferrous sulfate 28. Mercuric chloride 4. Diazepam 29. Thioridazine HCl 5. Amitriptyline 30. Thallium sulfate 6. Digoxin 31. Warfarin 7. Ethylene glycol 32. Lindane 8. Methyl alcohol 33. Chloroform 9. Ethyl alcohol 34. Carbon tetrachloride 10. Isopropyl alcohol 35. Isoniazid 11. 1,1,1-Trichloroethane 36. Dichloromethane 12. Phenol 37. Barium nitrate 13. Sodium chloride 38. Hexachlorophene 14. Sodium fluoride 39. Pentachlorophenol 15. Malathion 40. Verapamil HCl 16. 2,4-Dichlorophenoxyacetic acid 41. Chloroquine pholphate 17. Xylene 42. Orphenadrine HCl 18. Nicotine 43. Quinidine sulfate 19. Potassium cyanide 44. Diphenylhydantoin 20. Lithium sulfate 45. Chloramphenicol 21. Theophylline 46. Sodium oxalate 22. Dextropropoxyphene HCl 47. Amphetamine sulfate 23. Propranolol HCl 48. Caffeine 24. Phenobarbital 49. Atropine sulfate 25. Paraquat 50. Potassium chloride
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DOI: 10.1007/BF01795360
Affiliations:
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uniqKey="Stenberg K" first="Kjell" last="Stenberg">Kjell Stenberg</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Radiobiology, Karolinska Institute, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Walum, Erik" sort="Walum, Erik" uniqKey="Walum E" first="Erik" last="Walum">Erik Walum</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neurochemistry and Neurotoxicology, University of Stockholm, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell Biology and Toxicology</title><title level="j" type="abbrev">Cell Biol Toxicol</title><idno type="ISSN">0742-2091</idno><idno type="eISSN">1573-6822</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1989-11-01">1989-11-01</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="331">331</biblScope><biblScope unit="page" to="347">347</biblScope></imprint><idno type="ISSN">0742-2091</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0742-2091</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>basal cytotoxicity</term><term>general toxicity</term><term>in vitro cytotoxicity</term><term>multivariate toxicity modeling</term><term>testing</term><term>toxicokinetics</term><term>validation</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute toxicity</term><term>Animal tests</term><term>Atla</term><term>Basal</term><term>Basal cytotoxic concentration</term><term>Basal cytotoxicity</term><term>Bernson</term><term>Biotransformation</term><term>Blood concentration</term><term>Blood concentrations</term><term>Bondesson</term><term>Carcinogenicity tests</term><term>Cell biology</term><term>Cell lines</term><term>Cytotoxic</term><term>Cytotoxicity</term><term>Cytotoxicity tests</term><term>Different types</term><term>Dos</term><term>Dosage</term><term>Drug toxicity</term><term>Ekwall</term><term>Evaluation approach</term><term>Excretion</term><term>Food chem</term><term>General toxicity</term><term>Gross toxicity</term><term>Hellberg</term><term>Human hepatocytes</term><term>Human toxicity</term><term>Irritancy</term><term>Lethal dosage</term><term>Local irritancy</term><term>Local toxicity</term><term>Mechanistic</term><term>Meic</term><term>Meic study</term><term>Modeling</term><term>Multivariate</term><term>Multivariate data analysis</term><term>Physicochemical data</term><term>Predictivity</term><term>Quantitative toxicity</term><term>Reference chemicals</term><term>Romert</term><term>Stenberg</term><term>Stockholm</term><term>Such batteries</term><term>Sulfate</term><term>Systemic toxicity</term><term>Toxic</term><term>Toxic concentrations</term><term>Toxic dosage</term><term>Toxic effects</term><term>Toxic mechanisms</term><term>Toxicity</term><term>Toxicity testing</term><term>Toxicokinetic</term><term>Toxicokinetic models</term><term>Toxicol</term><term>Toxicology</term><term>Validation</term><term>Various cells</term><term>Walum</term><term>Whole model</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: A new international project to evaluate the relevance for human systemic and local toxicity of in vitro tests of general toxicity of chemicals has been organized by the Scandinavian Society of Cell Toxicology under the title 1Multicenter Evaluation of In Vitro Cytotoxicity (MEIC). The basic assumptions underlying the project, as well as the practical goals and the design of the program are outlined. The list of the first 50 reference chemicals is presented. The chemicals are an otherwise unbiased selection of compounds with known human acutely lethal dosage and blood concentrations, including LD50-values in the rat or mouse. Most agents also have other data on human toxicity and toxicokinetics, including more extensive animal toxicity data. International laboratories already using or developing in vitro tests of various partial aspects of general toxicity are invited to test the substances, the results of which will be evaluated by us. The predictivity of the in vitro results for both partial and gross human toxicity data will be determined with combined use of univariate regression analysis and soft multivariate modeling. The predictivity of the in vitro results will be compared with the predictivity of conventional animal tests for the same chemicals. Finally, batteries of tests with optimal prediction power for various types of human toxicity will be selected. The need for and possible uses of such batteries are discussed. TABLE 1 The First 50 Reference Chemicals of the MEIC Project 1. Acetaminophen 26. Arsenic trioxide 2. Aspirin 27. Cupric sulfate 3. Ferrous sulfate 28. Mercuric chloride 4. Diazepam 29. Thioridazine HCl 5. Amitriptyline 30. Thallium sulfate 6. Digoxin 31. Warfarin 7. Ethylene glycol 32. Lindane 8. Methyl alcohol 33. Chloroform 9. Ethyl alcohol 34. Carbon tetrachloride 10. Isopropyl alcohol 35. Isoniazid 11. 1,1,1-Trichloroethane 36. Dichloromethane 12. Phenol 37. Barium nitrate 13. Sodium chloride 38. Hexachlorophene 14. Sodium fluoride 39. Pentachlorophenol 15. Malathion 40. Verapamil HCl 16. 2,4-Dichlorophenoxyacetic acid 41. Chloroquine pholphate 17. Xylene 42. Orphenadrine HCl 18. Nicotine 43. Quinidine sulfate 19. Potassium cyanide 44. Diphenylhydantoin 20. Lithium sulfate 45. Chloramphenicol 21. Theophylline 46. Sodium oxalate 22. Dextropropoxyphene HCl 47. Amphetamine sulfate 23. Propranolol HCl 48. Caffeine 24. Phenobarbital 49. Atropine sulfate 25. Paraquat 50. Potassium chloride</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Bondesson, Inger" sort="Bondesson, Inger" uniqKey="Bondesson I" first="Inger" last="Bondesson">Inger Bondesson</name></region><name sortKey="Ekwall, Bjorn" sort="Ekwall, Bjorn" uniqKey="Ekwall B" first="Björn" last="Ekwall">Björn Ekwall</name><name sortKey="Hellberg, Sven" sort="Hellberg, Sven" uniqKey="Hellberg S" first="Sven" last="Hellberg">Sven Hellberg</name><name sortKey="Romert, Lennart" sort="Romert, Lennart" uniqKey="Romert L" first="Lennart" last="Romert">Lennart Romert</name><name sortKey="Stenberg, Kjell" sort="Stenberg, Kjell" uniqKey="Stenberg K" first="Kjell" last="Stenberg">Kjell Stenberg</name><name sortKey="Walum, Erik" sort="Walum, Erik" uniqKey="Walum E" first="Erik" last="Walum">Erik Walum</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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